The missing link has been discovered.
If you did not experience the sexual enhancement and anabolic effects of boosting your testosterone level, chances are... you're under attack by...
The Three Enemies of Testosterone
As men ages, we suffer from the dual effects of having too little testosterone and too much estrogen. The result is a testosterone/estrogen imbalance which severely inhibit sexual desire and performance.
Estrogen is converted from testosterone via a process known as aromatase. And aromatase is the first enemy of testosterone. The more testosterone gets converted to estrogen, the less we have for ourselves. Hence the first we want to do is to inhibit aromatase.
The second enemy of testosterone is estrogen. In youth, low amounts of estrogen are used to turn off the powerful cell-stimulating effects of testosterone. However as estrogen levels increase with age, testosterone cell stimulation may be locked in the "off" position, thus reducing sexual arousal and sensation and causing the loss of libido which is common in older men.
Estrogen is taken up by testosterone receptor sites in cells throughout the body. When an estrogen molecule occupies a testosterone receptor site on a cell membrane, it blocks the ability of testosterone to induce a healthy hormonal signal. It does not matter how much free testosterone is available if excess estrogen is competing for the same cellular receptor sites.
Moreover high serum levels of estrogen also trick the brain into thinking that enough testosterone is being produced, thereby slowing the natural production of testosterone.
Finally excess estrogen can also increase the production of SHBG (sex hormone binding globulin) which is the third enemy of testosterone.
Testosterone is the hormone responsible for sex drive and performance in men. For it to work its magic though, testosterone must be freely available to cell receptor sites in the brain, the nerves, muscles and genitals. As we age, SHBG increases and as a result more testosterone becomes bound to it.
As a result, the testosterone becomes unavailable in our body. For testosterone to produce long-lasting libido enhancing effects, it must be kept in the "free" form in the bloodstream. Testosterone bounded to SHBG cannot be used.
So what has to be done is not just to increase our overall testosterone production, but also to eliminate the effects from the 3 enemies of testosterone and they are:
- Aromatase (conversion of testosterone to estrogen)
- SHBG binding to testosterone
- Excess Estrogen
By inhibiting aromatase, two important functions are achieve.
- We have higher level of testosterone
- The amount of estrogen is reduced.
Too much estrogen wrecks havoc with a man's sex life by binding to testosterone receptor sites and may contribute to the over-production of SHBG. SHBG then binds free testosterone in a way that makes it unavailable to receptor sites in the brain, nerves and genitals. Excess estrogen also signal to our brain to limit the production of testosterone.
Finally, action must be taken to the binding of SHBG to testosterone.
Hence For aging men, it is desirable to suppress excess levels of SHBG and estrogen while boosting free testosterone to the level of a young man.
To reiterate, the hormone modulation objectives that most aging men need to facilitate sexual rejuvenation involves an increase in testosterone production coupled by a reduction in aromatase along with decrease in both estrogen and SHGD levels. This leads to a increase in 'free' testosterone which gives us the sexual enhancement and anabolic effects.
Destroying the First Enemy of Testosterone - Aromatase
A bioflavonoid known as chrysin has shown great potential as a natural aromatase-inhibitor when it was first isolated. The problem though is chrysin cannot be readily absorped into the bloodstream. As a result it did not produced the testosterone enhancing effects users expected.
However a breakthrough discovery was made in 1999. In a study published in Biochemical Pharmacology (1999, Vol.58), the specific mechanisms of chrysin's absorption impairment were identified. It was found that the addition of a pepper extract (piperine) significantly enhances the bioavailability of chrysin. Studies have found that when chrysin is combined with piperine, reductions in serum estrogen (estradiol) and increases in total and free testosterone result in 30 days.
In a study published in the Journal of Steroid Biochemical Molecular Biology (1993;Vol 46, No 3), chrysin and 10 other flavonoids were compared to an aromatase-inhibiting drug (aminoglutethimide). The study tested the aromatase-inhibiting effects of these natural flavonoids (such as genistein, rutin, tea catechins, etc.) in human fat cell cultures. Chrysin was the most potent aromatase-inhibitor, and was shown to be similar in potency and effectiveness to the aromatase-inhibiting drug.
The scientists conducting the study concluded by stating that the aromatase-inhibiting effects of certain flavonoids may contribute to the cancer preventive effects of plant-based diets.
More scientific studies
Two recent studies have identified specific mechanisms by which chrysin inhibits aromatase in human cells. These studies demonstrate that chrysin is a more potent inhibitor of the aromatase enzyme than phyto-estrogens and other flavonoids that are known to have aromatase-inhibiting properties (Arch Pharm Res 1999 Jun;22(3):309-12; J Steroid Biochem Mol Biol 1997 Apr;61(3-6):107-15).
The purpose of these studies was to ascertain which fruits and vegetables should be included in the diet of postmenopausal women to reduce the incidence of breast cancer. Excess levels of mutagenic forms of estrogen have been linked to a greater risk of breast cancer, and scientists are studying dietary means of naturally reducing levels of these dangerous estrogens.
Flavonoids such as chrysin are of considerable interest because they suppress excess estrogen via their aromatase-inhibiting properties. While this cancer preventing effect is most important for women, inhibiting aromatase in aging men has tremendous potential for naturally suppressing excess estrogen while boosting low levels of testosterone to a youthful state.
An advantage to using plant extracts to boost testosterone instead of drugs is that the plant extracts have ancillary health benefits.
Chrysin has one other property that could add to its libido-enhancing potential. A major cause of sexual dissatisfaction among men is work-related stress and anxiety. Another problem some men have is "sexual performance anxiety" that prevents them from being able to achieve erections when they are expected to.
In a study published in Pharmacology Biochemistry and Behavior (1994, Vol 47), mice were injected with diazepam (Valium), chrysin or placebo to evaluate the effects these substances had on anxiety and performance levels.
Chrysin was shown to produce anti-anxiety effects comparable with diazepam, but without sedation and muscle relaxation. In other words, chrysin produced a relaxing effect in the brain, but with no impairment of motor activity. The mechanism of action of chrysin was compared to diazepam, and it was shown that unlike diazepam, chrysin can reduce anxiety without inducing the common side-effects associated with benzodiazepine drugs.
Chrysin therefore offers sexual enhancment effects in male by:
- inhibiting the aromatase enzyme
- hence decreasing excess estrogen and increasing free testosterone
- couple with anti-anxiety and stress reduction effect
Eliminating the Second Enemy of Testosterone - SHBG Binding
Testosterone that becomes bound to SHBG (sex hormone-serum globulin) is rendered biologically inactive. It is no longer able to bind to testosterone receptors to produce the sexual and anabolic effects. Only testosterone that are not bound to SHBG can be utilized by our body.
These are known as 'free testosterone'.
As we age, the level of SHBG within our body increases and incidentally... coincides with the loss of libido. And this is not an accident.
Studies have shown that the decline in sexual interest with age is not always due to the total amount of testosterone produced, but rather to the increased binding of testosterone to SHBG. In other words, lesser free testosterone.
This explains why men who are on testosterone replacement therapy do not report a long-term aphrodisiac effect. What happened is artificially administered testosterone becomes bound by SHBG, and is not bioavailable to cellular receptor sites where it would normally produce a libido/sexual enhancing effect.
Therefore to increase the amount of free testosterone circulating in our body, the key is to reduce the binding of testosterone to SHBG.
A highly concentrated extract from the nettle root provides a unique mechanism for increasing levels of free testosterone. Recent European research has identified constituents of nettle root that bind to SHBG in place of testosterone, thus reducing SHBG's binding of free testosterone. As the authors of one study state:
"these constituents of nettle root may influence the blood level of free, i.e. active, steroid hormones by displacing them from the SHBG bindings site"
The prostate gland also benefits from nettle root. In Germany, nettle root has been used as a treatment for benign prostatic hyperplasia (enlargement of the prostate gland) for decades. A metabolite of testosterone called dihydrotestosterone (DHT) stimulates prostate growth, leading to enlargement. Nettle root inhibits the binding of DHT to attachment sites on the prostate membrane.
Detoxifying the Third Enemy of Testosterone - Excess Estrogen
Excessive estrogen in men is responsible for more maladies than you can possibly imagine. Besides suppressing testosterone levels, estrogen has been indicted in diseases of all sorts from cancer, to heart disease to prostate enlargement.
The truth of the matter is... even if you're not looking to enhance your testosterone production, you want to get rid of excess estrogen in your body just to maintain good health.
So what's a natural and safe ingredient that will eliminate the excess estrogen in our body?
The answer: Diindolylmethane (DIM)
DIMDiindolylmethane (DIM) is produced when the substance indole-3-carbinol (I3C) is digested. I3C is found primarily in cruciferous vegetables such as watercress, Brussel sprouts, broccoli, cauliflower and cabbage.
Oral supplementation of DIM has been shown to have potent effects on the liver’s metabolism of excess estrogen.
In small amounts, DIM can both inhibit the aromatase enzyme (and prevent conversion of testosterone into estrogen) and it can act on more potent forms of estrogen and convert them into less potent forms; this conversion reduces the overall effects of estrogen in the body.DIM also exerts numerous anti-carcinogenic (anti-cancer) effects in the body and is one of the reasons this vegetable family is seen as healthy.
Mechanism of Action
DIM is not an estrogen or a hormone, but like estrogen DIM can be metabolized only by a special class of cytochrome enzymes that reside in cell membranes in the non-water part of cells. It turns out that DIM, when consumed in food or in absorbable formulations, encourages its own metabolism. This special metabolic pathway for DIM, and the enzymes involved, precisely overlap with the pathway needed for healthy estrogen metabolism.
Stated simply, supplementing the diet with DIM specifically promotes beneficial estrogen metabolism and helps restore a healthy hormonal balance.
Putting it all together
Without a doubt, boosting our testosterone to youthful level is critical to reclaiming our youthful energy and sexual vitality.
But equally important is to search out and destroy these 3 enemies of testosterone, without which the increase in testosterone is rendered useless. It gets converted to estrogen or get binds to SHBG.
With this in mind, we created AE-3, an advance nutritional formula design to destroy these 3 enemies of testosterone.
One contains 500 mg of chrysin pure extract, combined with Bioperin® to enhance bio-availability, to safely and effectively inhibit aromatase. It also contains stinging nettle roots to reduce binding of testosterone to SHBG. This serves to increase our free testosterone level which is the real hormonal gold that does the heavy lifting. The last ingredient is DIM, which keeps estrogen at its optimal levels for maximum testosterone production.
Together, you have the most powerful formula for keeping your free testosterone at optimum level and eliminating excess estrogen.
100% Percent Satisfaction Guarantee
If you're not completely satisfied that AE-3 is the most powerful nutritional supplement to inhibit aromatase, block SHBG and detoxify excess estrogen, simply email us for a full refund. You'll get all your money back, no questions asked.
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By the way, the 'Free bottle offer' (also our most popular offer) is only good for a limited period of time depending on the demand for AE-3. Judging from the look of things though... it is very likely that this offer will go offline real soon. So take advantage of it while it is still available.
Sam Lee Harrison
Pure Science Supplements
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